Protein Modification Reagents
NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480452.JPG-250.jpg)
eMolecules DBCO-PEG-Silane, MW 5,000 | Broadpharm |666.891 | C35H50N4O7Si | 0.000 | CCO[Si](CCCNC(=O)NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419
DBCO-PEG-Silane, MW 5,000 | Broadpharm |666.891 | C35H50N4O7Si | 0.000 | CCO[Si](CCCNC(=O)NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419
eMolecules 1235514-18-7 | t-Boc-Aminooxy-PEG3-amine | Broadpharm | MFCD24471202 | 308.375 | C13H28N2O6 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCOCCN | 500mg | 303671296
t-Boc-Aminooxy-PEG3-amine | Broadpharm | 1235514-18-7 | MFCD24471202 | 308.375 | C13H28N2O6 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCOCCN | 500mg | 303671296
Medchemexpress LLC Propanoic acid, PEG4-NHPI pentafluorophenyl ester | 2101206-46-4 | >97.0% | 577.45 | C25H24F5NO9 | 100 MG
NHPI-PEG4-C2-Pfp ester is a PEG4-based pentafluorophenyl-activated linker reagent used for antibody-drug conjugate synthesis and other bioconjugation applications.
- Used as a linker reagent for antibody-drug conjugates and bioconjugation.
- High purity (≥97.0% by NMR).
- Molecular weight 577.45; chemical formula C25H24F5NO9.
- Colorless to light yellow liquid appearance.
- Storage: pure form -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC DSPE-PEG-Folate | 1236288-25-7 | 98.22% | C65H114N11O16P | 25 MG
DSPE-PEG-Folate is a PEG derivative containing folic acid with a targeting effect that binds to folate receptors in cancer cells. It forms micelles/lipid bilayers and can be used for targeted drug delivery system research. Nanoparticles constructed with DSPE-PEG-Folate and anticancer drugs primarily enter cells through the endocytosis pathway mediated by FA receptors. These nanoparticles mainly accumulate in the cytoplasm, and the released drugs are distributed in the cytoplasm and nucleus, effectively delivering drugs to the nucleus. It can also increase the elimination half-life of the drug and prolong blood circulation time.
- Contains folic acid
- Binds to folate receptors in cancer cells
- Forms micelles and lipid bilayers
- Supports targeted drug delivery system research
- Enables endocytosis pathway entry for nanoparticles
- Increases drug elimination half-life
- Prolongs blood circulation time
Cayman Chemical dPE-PEG 2000 MaleImIde 50mg
A MEK inhibitor (IC50 5.73 nM) and an active metabolite of CI-1040 reduces viral titers in A549 and MDCK cells infected with influenza A (EC50s 6.356 and 4.498 UM respectively) increases survival in H1N1pdm09 influenza A-infected mice at 50 mg/kg per day
![Carbosynth LLC. Cyclo[Arg-Ala-Asp-D-Tyr-Lys(PEG)], 25mg, MF= C34H54N10O11](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501952425.jpg-250.jpg)
Carbosynth LLC. Cyclo[Arg-Ala-Asp-D-Tyr-Lys(PEG)], 25mg, MF= C34H54N10O11
Application: Control peptide for RGD-3000-PI, salt: Trifluoroacetate Salt, one letter code: c[RADyK(PEG)], MW: 778.87
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB | 1949793-41-2 | 777.86 | C36H55N7O12 | 100 MG
Mal-PEG4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker containing a maleimide thiol-reactive group, a PEG4 spacer, a valine-citrulline (Val-Cit) protease-cleavable dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer. It is supplied as a solid for use in synthesis of ADC drug-linkers and for conjugation to thiol-containing antibodies.
- Maleimide thiol-reactive functional group
- PEG4 spacer improves solubility and spacing
- Val-Cit dipeptide cleavable by proteases such as cathepsin
- PAB self-immolative spacer enables payload release after cleavage
- Supplied as a solid suitable for conjugation workflows
Medchemexpress LLC Dbco-PEG5-NHS ester | 2144395-59-3 | 693.74 g/mol | C36H43N3O11 | 50 MG
Dbco-PEG5-NHS ester is a heterobifunctional, PEG-based bioorthogonal linker that combines a dibenzocyclooctyne (DBCO) moiety for strain-promoted alkyne-azide cycloaddition with an N-hydroxysuccinimide (NHS) ester for selective coupling to primary amines. It is intended for use in bioconjugation workflows such as antibody-drug conjugate and PROTAC synthesis, and for copper-free click chemistry and surface labeling.
- Enables copper-free click conjugation to azide-containing molecules via the DBCO group.
- Allows rapid amine coupling through the NHS ester at pH 7-9.
- PEG5 spacer improves solubility and reduces steric hindrance.
- Supplied as a small-scale reagent suitable for research and development work.
Medchemexpress LLC Boc-NH-PEG4-CH2COOH | 876345-13-0 | MFCD30528568 | >97.0% | 351.39 g/mol | C15H29NO8 | 250 MG
Boc-NH-PEG4-CH2COOH is a Boc-protected PEG4 linker with a terminal carboxylic acid offered for research use. It is used as a cleavable linker in antibody-drug conjugates (ADCs) and as a PEG-based linker in PROTAC synthesis. The product is supplied in multiple package sizes and is provided with analytical purity appropriate for research applications.
- Boc-protected PEG4 linker with terminal carboxylic acid.
- Suitable for ADC and PROTAC linker applications.
- High reported purity for research use.
- Available in small-scale and bulk package sizes.
- Molecular weight 351.39 g/mol; formula C15H29NO8.
Medchemexpress LLC Amino-PEG4-CH2COOH | 195071-49-9 | ≥98.0% | 251.28 g/mol | C10H21NO6 | 250 MG
Amino-PEG4-CH2COOH is a four-unit polyethylene glycol (PEG4) linker bearing a terminal amino group and a carboxylic acid (-CH2COOH). It is used as a hydrophilic spacer in bioconjugation chemistries such as PROTAC and antibody-drug conjugate (ADC) synthesis.
- Four-unit PEG spacer providing flexibility and solubility.
- Terminal amino and carboxylic acid functionalities for straightforward conjugation.
- High chemical purity suitable for research applications.
- Molecular weight approximately 251.28 g/mol, formula C10H21NO6.
- Available in common lab pack sizes, including 250 MG for small-scale synthesis.
Medchemexpress LLC Dbco-peg4-pfp ester | 2182601-19-8 | 95.0% | C36H35F5N2O8 | 100 MG
DBCO-PEG4-PFP ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This allows it to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Peg-based protac linker
- Utilized in protac synthesis
- Functions as a click chemistry reagent
- Contains a dbco group for spaac reactions
- Facilitates selective degradation of target proteins
- Appears as a colorless to light yellow oil
- Purity of 95.0%
- Molecular weight: 718.66
- Molecular formula: C36H35F5N2O8
Medchemexpress LLC m-PEG20-alcohol 1g
m-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC 2,5,8,11-Tetraoxatridecane, 13-azido- | 606130-90-9 | 98.0% | C9H19N3O4 | 50 MG
2,5,8,11-Tetraoxatridecane, 13-azido- is a chemical compound with a molecular weight of 233.26. It appears as a colorless to light yellow liquid and is intended for research use only. This product has been tested and complies with the given specifications.
- Colorless to light yellow liquid appearance
- Molecular weight of 233.26
- Suitable for research applications
- Storage in pure form at -20°C for 3 years
- Storage in solvent at -80°C for 6 months
- Storage in solvent at -20°C for 1 month