Protein Modification Reagents
ABclonal Technology RIN2 Rabbit pAb
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.
ABclonal Technology ATP23 Rabbit pAb
The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology NRIP2 Rabbit pAb
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in cytoplasm.
ABclonal Technology NRIP2 Rabbit pAb
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in cytoplasm.
Chemscene ChemScene | Azido-PEG5-amine | 1G | CS-0114401 | 0.97 | 516493-93-9| MFCD16619318 | 306.36
ChemScene | Azido-PEG5-amine | 1G | CS-0114401 | 0.97 | 516493-93-9| MFCD16619318 | 306.36
Medchemexpress LLC (S,R,S)-AHPC-PEG2-C4-Cl | 1835705-57-1 | MFCD31560480 | 98.2% | 651.26 g/mol | C32H47ClN4O6S | 2 G
A VHL ligand-linker conjugate used as a PROTAC building block; it incorporates the (S,R,S)-AHPC VHL ligand connected via a PEG2-C4 alkyl/ether linker with a terminal chloride and has been reported to induce degradation of GFP-HaloTag7 in cell-based assays.
- Used as a building block for PROTAC synthesis and E3 ligase ligand-linker conjugates.
- Contains a VHL-binding (S,R,S)-AHPC motif with a PEG2-C4 linker.
- Reported to induce GFP-HaloTag7 degradation in cell assays.
- Soluble in DMSO, water, and ethanol at approximately 50 mg/mL (may require ultrasonic).
- Available in multiple package sizes, including a 2 g option.
![eMolecules Broadpharm / N-DBCO-N-bis(PEG2-amide-PEG4-Val-cit-PAB-MMAE) / 1mg / 718091677 / BP-28218 / 98.000 / / [null] / 3330.135 / C171H266N24O42](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502474726.JPG-250.jpg)
eMolecules Broadpharm / N-DBCO-N-bis(PEG2-amide-PEG4-Val-cit-PAB-MMAE) / 1mg / 718091677 / BP-28218 / 98.000 / / [null] / 3330.135 / C171H266N24O42
Broadpharm / N-DBCO-N-bis(PEG2-amide-PEG4-Val-cit-PAB-MMAE) / 1mg / 718091677 / BP-28218 / 98.000 / / [null] / 3330.135 / C171H266N24O42
![eMolecules Broadpharm / DBCO-PEG8-amine TFA salt / 50mg / 698442848 / BP-25732 / / / [null] / 699.842 / C37H53N3O10](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475244.JPG-250.jpg)
eMolecules Broadpharm / DBCO-PEG8-amine TFA salt / 50mg / 698442848 / BP-25732 / / / [null] / 699.842 / C37H53N3O10
Broadpharm / DBCO-PEG8-amine TFA salt / 50mg / 698442848 / BP-25732 / / / [null] / 699.842 / C37H53N3O10
Medchemexpress LLC Thiol-PEG2-t-butyl ester | 1398044-50-2 | MFCD22574781 | 96.0% | 250.35 g·mol-1 | C11H22O4S | 5 MG
Thiol-PEG2-t-butyl ester is a short polyethylene glycol (PEG2) linker bearing a tert-butyl-protected thiol, designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It provides a hydrophilic spacer and a masked thiol functionality for selective deprotection and conjugation in medicinal chemistry workflows.
- Provides a short PEG2 spacer to improve solubility and flexibility.
- Contains a tert-butyl-protected thiol for masked thiol chemistry.
- Suitable for incorporation into bifunctional PROTAC molecules.
- Available in research-scale pack sizes for synthetic work.
- Molecular weight ~250.35 g·mol-1 and formula C11H22O4S.